The Scot joins his brother, Marino Franchitti, Ferrari Challenge UK champion Jamie Clarke, journalist Dickie Meaden and ex-Army Corporal Sophie Burt, who is a beneficiary of the Mission Motorsport programme in a unique team line-up.
A Mazda MX-5 prepared by Mission Motorsport employees and beneficiaries will form part of the 50-strong field that will take part in the endurance race.
Franchitti said he was honoured to be a part of the 2019 race and involved with the charity.
“It’s a real honour to race with Sophie and Mission Motorsport,” Franchitti said.
“I have a great appreciation for the charity and while I’ve never raced at Anglesey before I can’t wait to get out there.”
James Cameron, CEO, Mission Motorsport added that the opportunity to have the three-time Indy 500 winner join the line-up would greatly add to the event.
“I’m still pinching myself. To have Dario, Marino, Dickie and Jamie join Sophie in a team run by Mission Motorsport will not only make a huge difference to her but also shine a light on a unique event that truly aids the recovery journey of so many others.”
The 12-hour race will take place on the weekend of November 9-10 and is suspended at 11am on Remembrance Sunday before being restarted and finishing at 3pm later the same day. The 2019 race will be the sixth running of the charity event.